The TIGIT⁺ T regulatory cells subset associates with nosocomial infection and fatal outcome in COVID-19 patients under mechanical ventilation.

ABSTRACT: The TIGIT⁺FOXP3⁺Treg subset (TIGIT⁺Tregs) exerts robust suppressive activity on cellular immunity and predisposes septic individuals to opportunistic infection. We hypothesized that TIGIT⁺Tregs could play an important role in intensifying the COVID-19 severity and hampering the defense against nosocomial infections during hospitalization. Herein we aimed to verify the association between the levels of the TIGIT⁺Tregs with the mechanical ventilation requirement, fatal outcome, and bacteremia during hospitalization. TIGIT⁺Tregs were immunophenotyped by flow cytometry from the peripheral blood of 72 unvaccinated hospitalized COVID-19 patients at admission from May 29th to August 6th, 2020. The patients were stratified during ho

SUBMITTER: de Lima MHF 

PROVIDER: S-EPMC10442317 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature