Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes.

ABSTRACT: Functional somatic syndromes (FSS) include fibromyalgia, irritable bowel syndrome (IBS), and others. In FSS patients, merely viewing negative affective pictures can elicit increased physical symptoms. Our aim was to investigate the neural mechanisms underlying such negative affect-induced physical symptoms in FSS patients. Thirty patients with fibromyalgia and/or IBS and 30 healthy controls (all women) watched neutral, positive and negative affective picture blocks during functional MRI scanning and rated negative affect and physical symptoms after every block. We compared brain-wide activation during negative versus neutral picture viewing in FSS patients versus controls using robust general linear model analysis. Further, we compared neurologic pain signature (NPS), stimulus intensity-in

SUBMITTER: Bogaerts K 

PROVIDER: S-EPMC10442365 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature