Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized ¹³C-labelled Z-OMPD.

ABSTRACT: pH alterations are a hallmark of many pathologies including cancer and kidney disease. Here, we introduce [1,5-¹³C₂]Z-OMPD as a hyperpolarized extracellular pH and perfusion sensor for MRI which allows to generate a multiparametric fingerprint of renal disease status and to detect local tumor acidification. Exceptional long T₁ of two minutes at 1 T, high pH sensitivity of up to 1.9 ppm per pH unit and suitability of using the C₁-label as internal frequency reference enables pH imaging in vivo of three pH compartments in healthy rat kidneys. Spectrally selective targeting of both ¹³C-resonances enables simultaneous imaging of perfusion and filtration in 3D and pH in 2D within one minute to quantify renal blood flow, glomerular filtratio

SUBMITTER: Grashei M 

PROVIDER: S-EPMC10442412 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature