Regulatory roles of Osteopontin in lung epithelial inflammation and epithelial-telocyte interaction.

ABSTRACT:

Background

Lung epithelial cells play important roles in lung inflammation and injury, although mechanisms remain unclear. Osteopontin (OPN) has essential roles in epithelial damage and repair and in lung cancer biological behaviours. Telocyte (TC) is a type of interstitial cell that interacts with epithelial cells to alleviate acute inflammation and lung injury. The present studies aim at exploring potential mechanisms by which OPN regulates the epithelial origin lung inflammation and the interaction of epithelial cells with TCs in acute and chronic lung injury.

Methods

The lung disease specificity of OPN and epithelial inflammation were defined by bioinformatics. We evaluated the regulatory roles of OPN in OPN-knockdown or over-expressed bronchial epithelia (HBEs) challeng

SUBMITTER: Fu H 

PROVIDER: S-EPMC10442477 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature