Circulating Vitamin D Level and Risk of Sudden Cardiac Death and Cardiovascular Mortality: A Dose-Response Meta-Analysis of Prospective Studies.

ABSTRACT:

Background

We conducted a comprehensive meta-analysis of prospective cohort studies to analyze the effect of circulating vitamin D level on the risk of sudden cardiac death (SCD) and cardiovascular disease (CVD) mortality.

Methods

Prospective cohort studies evaluating the association between circulating vitamin D and risk of SCD and CVD mortality were systematically searched in the PubMed and Embase. Extracted data were analyzed using a random effects model and results were expressed in terms of hazard ratio (HR) and 95% confidence interval (CI). Restricted cubic spline analysis was used to estimate the dose-response relationships.

Results

Of the 1,321 records identified using the search strategy, a total of 19 cohort studies were included in the final meta-analysis.

SUBMITTER: Kong SY 

PROVIDER: S-EPMC10442497 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature