A pilot in vivo study: potential ovarian cancer therapeutic by placental extracellular vesicles.

ABSTRACT: The biological links between cancer and pregnancy are of interest due to parallel proliferative, immunosuppressive, and invasive mechanisms between tumour and placental cells. However, the proliferation and invasion of placental cells are strictly regulated. The understanding of this regulation is largely unknown. Placental extracellular vesicles (EVs) may play an important role in this regulation, as placental EVs are known to contribute to maternal adaptation, including adaptation of the vascular and immune systems. We have previously reported that placental EVs significantly inhibited ovarian cancer cell proliferation by delaying the progression of the cell cycle. We, therefore, performed this pilot in vivo study to investigate whether placental EVs can also inhibit ovarian tumour growt

SUBMITTER: Chen X 

PROVIDER: S-EPMC10442519 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature