Human-to-swine introductions and onward transmission of 2009 H1N1 pandemic influenza viruses in Brazil.

ABSTRACT:

Introduction

Once established in the human population, the 2009 H1N1 pandemic virus (H1N1pdm09) was repeatedly introduced into swine populations globally with subsequent onward transmission among pigs.

Methods

To identify and characterize human-to-swine H1N1pdm09 introductions in Brazil, we conducted a large-scale phylogenetic analysis of 4,141 H1pdm09 hemagglutinin (HA) and 3,227 N1pdm09 neuraminidase (NA) gene sequences isolated globally from humans and swine between 2009 and 2022.

Results

Phylodynamic analysis revealed that during the period between 2009 and 2011, there was a rapid transmission of the H1N1pdm09 virus from humans to swine in Brazil. Multiple introductions of the virus were observed, but most of them resulted in self-limited infections in swine, with

SUBMITTER: Junqueira DM 

PROVIDER: S-EPMC10442540 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature