Frontal adenosine triphosphate markers from ³¹P MRS are associated with cognitive performance in healthy older adults: preliminary findings.

ABSTRACT: Aging is associated with declines in mitochondrial efficiency and energy production which directly impacts the availability of adenosine triphosphate (ATP), which contains high energy phosphates critical for a variety of cellular functions. Previous phosphorous magnetic resonance spectroscopy (³¹P MRS) studies demonstrate cerebral ATP declines with age. The purpose of this study was to explore the functional relationships of frontal and posterior ATP levels with cognition in healthy aging. Here, we measured frontal and posterior ATP levels using ³¹P MRS at 3 Tesla (3 T) and assessed cognition using the Montreal Cognitive Assessment (MoCA) in 30 healthy older adults. We found that greater frontal, but not posterior, ATP levels were significantly associated with better

SUBMITTER: Lopez FV 

PROVIDER: S-EPMC10442546 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature