Classification of genotypes based on the VP1 gene of feline calicivirus and study of cross-protection between different genotypes.

ABSTRACT: Feline calicivirus (FCV) causes upper respiratory tract diseases and even death in cats, thereby acting as a great threat to feline animals. Currently, FCV prevention is mainly achieved through vaccination, but the effectiveness of vaccination is limited. In this study, 105 FCV strain VP1 sequences with clear backgrounds were downloaded from the NCBI and subjected to a maximum likelihood method for systematic evolutionary analysis. Based on the genetic analysis results, FCV-positive sera were prepared using SPF mice and Chinese field cats as target animals, followed by a cross-neutralization assay conducted on the different genotype strains and in vivo challenge tests were carried out to further verify with the strain with best cross-protection effect. The results revealed that FCV

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10442547 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature