Distinct amyloid-dependent patterns of nigra dopamine depletion in Lewy body diseases.

ABSTRACT:

Introduction

Concomitant amyloid pathology is not uncommon and contributes to the clinical characteristics of Lewy body disease (LBD). We investigated the effect of amyloid on striatal¹⁸F-FP-CIT uptake patterns in LBD, including Parkinson's disease (PD) and dementia with Lewy bodies.

Methods

We enrolled 125 patients with LBD who underwent¹⁸F-florbetaben positron emission tomography (PET) and¹⁸F-FP-CIT PET. Patients were divided into amyloid-positive and amyloid-negative groups. We investigated the effect of amyloid on striatal dopamine transporter (DAT) availability, depending on the type of LBD, using general linear models with interaction analysis after controlling for age, sex, education, deep white matter hyperintensity (WMH), periventric

SUBMITTER: Baik K 

PROVIDER: S-EPMC10442581 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature