Lung toxicity and gene expression changes in response to whole-body inhalation exposure to cellulose nanocrystal in rats.

ABSTRACT:

Objective

Human exposure to cellulose nanocrystal (CNC) is possible during the production and/or use of products containing CNC. The objectives of the current study were to determine the lung toxicity of CNC and the underlying molecular mechanisms of the toxicity.

Methods

Rats were exposed to air or CNC (20 mg/m³, six hours/day, 14 d) by whole-body inhalation and lung toxicity and global gene expression profile were determined.

Results

Significant increases in lactate dehydrogenase activity, pro-inflammatory cytokine levels, phagocyte oxidant production, and macrophage and neutrophil counts were detected in the bronchoalveolar lavage cells or fluid from the CNC exposed rats. Mild lung histological changes, such as the accumulation of macrophages and neutrop

SUBMITTER: Joseph P 

PROVIDER: S-EPMC10442725 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature