Fine-tuning the cytotoxicity of ruthenium(II) arene compounds to enhance selectivity against breast cancers.

ABSTRACT: Ruthenium-based complexes have been suggested as promising anticancer drugs exhibiting reduced general toxicity compared to platinum-based drugs. In particular, Ru(η⁶-arene)(PTA)Cl₂ (PTA = 1,3,5-triaza-7-phosphaadamantane), or RAPTA, complexes have demonstrated efficacy against breast cancer by suppressing metastasis, tumorigenicity, and inhibiting the replication of the human tumor suppressor gene BRCA1. However, RAPTA compounds have limited cytotoxicity, and therefore comparatively high doses are required. This study explores the activity of a series of RAPTA-like ruthenium(II) arene compounds against MCF-7 and MDA-MB-231 breast cancer cell lines and [Ru(η⁶-toluene)(PPh₃)₂Cl]⁺ was identified as a promising candidate. Notab

SUBMITTER: Pereira SAP 

PROVIDER: S-EPMC10442743 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature