The association of genetically determined serum glycine with cardiovascular risk in East Asians.
Ontology highlight
ABSTRACT: Background and aims
Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians.Methods and results
We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138).Conclusion
Our study, a first in East Asians, suggest a protective role of glycine against CAD.
SUBMITTER: Chang X
PROVIDER: S-EPMC10442847 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
The association of genetically determined serum glycine with cardiovascular risk in East Asians.
Chang Xuling X Wang Ling L Guan Shou Ping SP Kennedy Brian K BK Liu Jianjun J Khor Chiea-Chuen CC Low Adrian F AF Chan Mark Yan-Yee MY Yuan Jian-Min JM Koh Woon-Puay WP Friedlander Yechiel Y Dorajoo Rajkumar R Heng Chew-Kiat CK
Nutrition, metabolism, and cardiovascular diseases : NMCD 20210407 6
<h4>Background and aims</h4>Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians.<h4>Methods and results</h4>We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated wit ...[more]
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