In utero exposure to diethylstilbestrol and blood DNA methylation in adult women: Results from a meta-analysis of two cohort studies.

ABSTRACT:

Background

Prenatal exposure to diethylstilbestrol (DES) is associated with several adverse health outcomes. Animal studies have shown associations between prenatal DES exposure and DNA methylation.

Objective

The aim of this study was to explore blood DNA methylation in women exposed and unexposed to DES in utero.

Methods

Sixty women (40 exposed and 20 unexposed) in the National Cancer Institute's Combined DES Cohort Study and 199 women (99 exposed and 100 unexposed women) in the Sister Study Cohort were included in this analysis. Within each study, robust linear regression models were used to assess associations between DES exposure and blood DNA methylation. Study-specific associations were combined using fixed-effect meta-analysis with inverse variance weights. Our

SUBMITTER: Bodelon C 

PROVIDER: S-EPMC10442904 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature