Regioselective C3-H Alkylation of Imidazopyridines with Donor-Acceptor Cyclopropanes.

ABSTRACT: Alkylated imidazopyridines are crucial structures for medicinal chemistry. Here, an efficient method for the C3-H alkylation of imidazopyridines was devised. Under Lewis acid-catalyzed conditions, reactions of imidazopyridines with different donor-acceptor cyclopropanes were carried out. Finally, 1,3-bisfunctionalizaton of donor-acceptor cyclopropanes was performed. In addition, synthesized C3-alkylated imidazopyridines are amenable for diverse synthetic applications.

SUBMITTER: Dalkilic O 

PROVIDER: S-EPMC10443042 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature