Transcriptome analysis of hydrogen inhibits osteoclastogenesis of mouse bone marrow mononuclear cells.

ABSTRACT: Hydrogen (H₂) is a major biodegradation product of implanted magnesium (Mg) alloys that are commonly used in the healing of bone fractures. Our earlier study showed that H₂ can inhibit mouse bone marrow mononuclear cell (BMMC) osteoclastogenesis during the differentiation of these cells into osteoclasts, thereby facilitating fracture healing. However, the way by which H₂ inhibits osteoclastogenesis remains to be elucidated. The present study used RNA-sequencing to study the transcriptome of H₂-exposed BMMCs in an osteoclast-induced environment and identified the target genes and signaling pathways through which H₂ exerts its biological effects. Several upregulated genes were identified: Fos, Dusp1, Cxcl1, Reln</

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10443061 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature