Fibrotic Marker Galectin-3 Identifies Males at Risk of Developing Cancer and Heart Failure.

ABSTRACT:

Background

Cancer and heart failure (HF) are the leading causes of death in the Western world. Shared mechanisms such as fibrosis may underlie either disease entity, furthermore it is unknown whether this relationship is sex-specific.

Objectives

We sought to investigate how fibrosis-related biomarker galectin-3 (gal-3) aids in identifying individuals at risk for new-onset cancer and HF, and how this differs between sexes.

Methods

Gal-3 was measured at baseline and at 4-year follow-up in 5,786 patients of the PREVEND (Prevention of Renal and Vascular Endstage Disease) study. The total follow-up period was 11.5 years. An increase of ≥50% in gal-3 levels between measurements was considered relevant. We performed sex-stratified log-rank tests and Cox regression analyses o

SUBMITTER: van den Berg PF 

PROVIDER: S-EPMC10443113 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature