Midlife Neuropsychological Profiles and Associated Vascular Risk: The Bogalusa Heart Study.

ABSTRACT:

Background

Individuals with Alzheimer's disease (AD) often present with coexisting vascular pathology that is expressed to different degrees and can lead to clinical heterogeneity.

Objective

To examine the utility of unsupervised statistical clustering approaches in identifying neuropsychological (NP) test performance subtypes that closely correlate with carotid intima-media thickness (cIMT) in midlife.

Methods

A hierarchical agglomerative and k-means clustering analysis based on NP scores (standardized for age, sex, and race) was conducted among 1,203 participants (age 48±5.3 years) from the Bogalusa Heart Study. Regression models assessed the association between cIMT ≥50th percentile and NP profiles, and global cognitive score (GCS) tertiles for sensitivity analysis

SUBMITTER: De Anda-Duran I 

PROVIDER: S-EPMC10443183 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature