Extensive Cardiac Function Analyses Using Contemporary Echocardiography in Childhood Cancer Survivors: A DCCSS LATER Study.

ABSTRACT:

Background

Childhood cancer survivors (CCS) are at risk for cardiotoxicity.

Objectives

We sought to assess how cardiac dysfunction measurements in CCS overlap and are differentially influenced by risk factors.

Methods

This cross-sectional Dutch Childhood Cancer Survivor Study evaluated echocardiograms of 1,397 ≥5-year CCS and 277 siblings. Of CCS, n = 1,254 received cardiotoxic (anthracyclines/mitoxantrone/radiotherapy involving the heart region [RT_heart]) and n = 143 received potentially cardiotoxic (cyclophosphamide, ifosfamide, or vincristine) therapy. We assessed demographic, treatment-related, and traditional cardiovascular risk factors for cardiac dysfunction using multivariable logistic regression.

Results

CCS were a median of 26.7 years after

SUBMITTER: Merkx R 

PROVIDER: S-EPMC10443197 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature