A phosphate-sensing organelle regulates phosphate and tissue homeostasis.

ABSTRACT: Inorganic phosphate (P_i) is one of the essential molecules for life. However, little is known about intracellular P_i metabolism and signalling in animal tissues¹. Following the observation that chronic P_i starvation causes hyperproliferation in the digestive epithelium of Drosophila melanogaster, we determined that P_i starvation triggers the downregulation of the P_i transporter PXo. In line with P_i starvation, PXo deficiency caused midgut hyperproliferation. Interestingly, immunostaining and ultrastructural analyses showed that PXo specifically marks non-canonical multilamellar organelles (PXo bodies). Further, by P_i imaging with a Förster resonance energy transfer (FRET)-based P_i sensor

SUBMITTER: Xu C 

PROVIDER: S-EPMC10443203 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature