Shift of N-MYC Oncogene Expression in AML Patients Carrying the FLT3-ITD Mutation.

ABSTRACT: Mutations in the FLT3 gene not only lead to abnormalities in its structure and function, but also affect the expression of other genes involved in leukemogenesis. This study evaluated the expression of genes that are more characteristic of neuroblastoma but less studied in leukemia. N-MYC oncogene expression was found to be more than 3-fold higher in primary AML patients carrying the FLT3-ITD mutation compared to carriers of other mutations as well as patients with normal karyotype (p = 0.03946). In contrast to the expression of several genes (C-MYC, SPT16, AURKA, AURKB) directly correlated to the allelic load of FLT3-ITD, the expression of the N-MYC oncogene is extremely weakly related or independent of it (p = 0

SUBMITTER: Bogdanov K 

PROVIDER: S-EPMC10443239 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature