Diphtheria toxin-derived, anti-PD-1 immunotoxin, a potent and practical tool to selectively deplete PD-1⁺ cells.

ABSTRACT: Programmed death-1 (PD-1), an immune checkpoint receptor, is expressed on activated lymphocytes, macrophages, and some types of tumor cells. While PD-1⁺ cells have been implicated in outcomes of cancer immunity, autoimmunity, and chronic infections, the exact roles of these cells in various physiological and pathological processes remain elusive. Molecules that target and deplete PD-1⁺ cells would be instrumental in defining the roles unambiguously. Previously, an immunotoxin has been generated for the depletion of PD-1⁺ cells though its usage is impeded by its low production yield. Thus, a more practical molecular tool is desired to deplete PD-1⁺ cells and to examine functions of these cells. We designed and generated a novel anti-PD1 diphtheria

SUBMITTER: Zhang T 

PROVIDER: S-EPMC10443333 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature