The core genome evolution of Lactobacillus crispatus as a driving force for niche competition in the human vaginal tract.

ABSTRACT: The lower female reproductive tract is notoriously dominated by Lactobacillus species, among which Lactobacillus crispatus emerges for its protective and health-promoting activities. Although previous comparative genome analyses highlighted genetic and phenotypic diversity within the L. crispatus species, most studies have focused on the presence/absence of accessory genes. Here, we investigated the variation at the single nucleotide level within protein-encoding genes shared across a human-derived L. crispatus strain selection, which includes 200 currently available human-derived L. crispatus genomes as well as 41 chromosome sequences of such taxon that have been decoded in the framework of this study. Such data clearly pointed out the presence of intra-species micro-diversities that coul

SUBMITTER: Tarracchini C 

PROVIDER: S-EPMC10443340 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature