The antioxidant vitamin E as a membrane raft modulator: Tocopherols do not abolish lipid domains.

ABSTRACT: The antioxidant vitamin E is a commonly used vitamin supplement. Although the multi-billion dollar vitamin and nutritional supplement industry encourages the use of vitamin E, there is very little evidence supporting its actual health benefits. Moreover, vitamin E is now marketed as a lipid raft destabilizing anti-cancer agent, in addition to its antioxidant behaviour. Here, we studied the influence of vitamin E and some of its vitamers on membrane raft stability using phase separating unilamellar lipid vesicles in conjunction with small-angle scattering techniques and fluorescence microscopy. We find that lipid phase behaviour remains unperturbed well beyond physiological concentrations of vitamin E (up to a mole fraction of 0.10). Our results are consistent with a proposed line active ro

SUBMITTER: DiPasquale M 

PROVIDER: S-EPMC10443432 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature