Rescue of follicle development after oocyte-induced ovary dysfunction and infertility in a model of POI.

ABSTRACT: The mechanisms and aetiology underlying the development of premature ovarian insufficiency (POI) are poorly understood. However, the oocyte clearly has a role as demonstrated by the Double Mutant (DM) mouse model where ovarian dysfunction (6 weeks) is followed by POI (3 months) due to oocyte-specific deletion of complex and hybrid N- and O-glycans. The ovaries of DM mice contain more primary follicles (3a stage) accompanied by fewer developing follicles, indicating a block in follicle development. To investigate this block, we first analysed early follicle development in postnatal (8-day), pre-pubertal (3-week) and post-pubertal (6-week and 3-month) DM (C1galt1 ^F/F Mgat1 ^F/F:ZP3Cre) and Control (C1galt1 ^F/F Mgat1 ^F/F<

SUBMITTER: Sheikh S 

PROVIDER: S-EPMC10443433 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature