Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification.

ABSTRACT: Sixty-six human enterovirus serotypes have been identified by serum neutralization, but the molecular determinants of the serotypes are unknown. Since the picornavirus VP1 protein contains a number of neutralization domains, we hypothesized that the VP1 sequence should correspond with neutralization (serotype) and, hence, with phylogenetic lineage. To test this hypothesis and to analyze the phylogenetic relationships among the human enteroviruses, we determined the complete VP1 sequences of the prototype strains of 47 human enterovirus serotypes and 10 antigenic variants. Our sequences, together with those available from GenBank, comprise a database of complete VP1 sequences for all 66 human enterovirus serotypes plus additional strains of seven serotypes. Phylogenetic trees constructed fr

SUBMITTER: Oberste MS 

PROVIDER: S-EPMC104435 | biostudies-literature | 1999 Mar

REPOSITORIES: biostudies-literature