A three-component difunctionalization of N-alkenyl amides via organophotoredox radical-polar crossover.

ABSTRACT: Herein, we report a three-component organophotoredox coupling of N-alkenyl amides with α-bromocarbonyls and various nucleophiles. This transition metal-free difunctionalization protocol installs sequential C-C and C-Y (Y = S/O/N) bonds in alkenes. This reaction works with terminal and internal alkenes containing both cyclic and acyclic amides via radical-polar crossover.

SUBMITTER: Dhungana RK 

PROVIDER: S-EPMC10443537 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature