Feasibility Assessment of a Biomarker-Guided Kidney-Sparing Sepsis Bundle: The Limiting Acute Kidney Injury Progression In Sepsis Trial.

ABSTRACT:

Objectives

To determine the feasibility, safety, and efficacy of a biomarker-guided implementation of a kidney-sparing sepsis bundle (KSSB) of care in comparison with standard of care (SOC) on clinical outcomes in patients with sepsis.

Design

Adaptive, multicenter, randomized clinical trial.

Setting

Five University Hospitals in Europe and North America.

Patients

Adult patients, admitted to the ICU with an indwelling urinary catheter and diagnosis of sepsis or septic shock, without acute kidney injury (acute kidney injury) stage 2 or 3 or chronic kidney disease.

Interventions

A three-level KSSB based on Kidney Disease: Improving Global Outcomes (KDIGOs) recommendations guided by serial measurements of urinary tissue inhibitor of metalloproteinases-2 and i

SUBMITTER: Gomez H 

PROVIDER: S-EPMC10443738 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature