U-Shaped Association Between Carboxyhemoglobin and Mortality in Patients With Acute Respiratory Distress Syndrome on Venovenous Extracorporeal Membrane Oxygenation.

ABSTRACT:

Background

Carbon monoxide (CO) is an endogenous signaling molecule that activates cytoprotective programs implicated in the resolution of acute respiratory distress syndrome (ARDS) and survival of critical illness. Because CO levels can be measured in blood as carboxyhemoglobin, we hypothesized that carboxyhemoglobin percent (COHb%) may associate with mortality.

Objectives

To examine the relationship between COHb% and outcomes in patients with ARDS requiring venovenous extracorporeal membrane oxygenation (ECMO), a condition where elevated COHb% is commonly observed.

Design

Retrospective cohort study.

Setting

Academic medical center ICU.

Patients

Patients were included that had ARDS on venovenous ECMO.

Measurements and main results

We examined the

SUBMITTER: Meservey A 

PROVIDER: S-EPMC10443764 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature