Self-application of aminoglycoside-based creams to treat cutaneous leishmaniasis in travelers.

ABSTRACT:

Background

In endemic foci, the use of an aquaphilic cream containing paromomycin with/without gentamicin to treat cutaneous leishmaniasis (CL) is safe, painless and cures 78-82% of patients with New and Old World CL. Self-application in travelers requires evaluation.

Methods

Travelers with 1-10 lesions of confirmed CL were prospectively treated with the paromomycin-gentamicin formulation (WR279396, 2012-2017, Group 1) and carefully follow up, or treated with a locally produced paromomycin-only cream (2018-2022, Group 2). The cream was applied once under supervision, then self-applied daily for 20-30 days. A cured lesion was defined as 100% re-epithelialization at day 42 without relapse at three months.

Results

Medical features were similar in Group 1 (17 patients), a

SUBMITTER: Mouri O 

PROVIDER: S-EPMC10443860 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature