SARS-CoV-2 infection perturbs enhancer mediated transcriptional regulation of key pathways.

ABSTRACT: Despite extensive studies on the effects of SARS-CoV-2 infection, there is still a lack of understanding of the downstream epigenetic and regulatory alterations in infected cells. In this study, we investigated changes in enhancer acetylation in epithelial lung cells infected with SARS-CoV-2 and their influence on transcriptional regulation and pathway activity. To achieve this, we integrated and reanalyzed data of enhancer acetylation, ex-vivo infection and single cell RNA-seq data from human patients. Our findings revealed coordinated changes in enhancers and transcriptional networks. We found that infected cells lose the WT1 transcription factor and demonstrate disruption of WT1-bound enhancers and of their associated target genes. Downstream targets of WT1 are involved in the regulatio

SUBMITTER: Yedidya Y 

PROVIDER: S-EPMC10443870 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature