Day-night fluctuations in choroid plexus transcriptomics and cerebrospinal fluid metabolomics.

ABSTRACT: The cerebrospinal fluid (CSF) provides mechanical protection for the brain and serves as a brain dispersion route for nutrients, hormones, and metabolic waste. The CSF secretion rate is elevated in the dark phase in both humans and rats, which could support the CSF flow along the paravascular spaces that may be implicated in waste clearance. The similar diurnal CSF dynamics pattern observed in the day-active human and the nocturnal rat suggests a circadian regulation of this physiological variable, rather than sleep itself. To obtain a catalog of potential molecular drivers that could provide the day-night-associated modulation of the CSF secretion rate, we determined the diurnal fluctuation in the rat choroid plexus transcriptomic profile with RNA-seq and in the CSF metabolomics with ultr

SUBMITTER: Edelbo BL 

PROVIDER: S-EPMC10443925 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature