Variants in the DRD2 locus and antipsychotic-related prolactin levels: A meta-analysis.

ABSTRACT:

Background

Although dopamine D2 receptor antagonists lead to dose-dependent prolactin (PRL) elevations proportionate to their D2 affinity, considerable inter-individual differences exist. We conducted a meta-analytic review of associations between genetic variations in the dopamine D2 receptor gene (DRD2) and PRL levels in antipsychotic-treated subjects.

Methods

Systematic literature search (5/8/2015) was performed to find published studies of pharmacogenetic associations between two DRD2 variants, Taq1A (rs1800497) and -141C Ins/Del (rs1799732), and PRL levels during antipsychotic treatment (excluding aripiprazole). Patients were included independent of age or diagnosis. Random effects models were used and Hedges' g was calculated as the effect size measure. Subgroup analys

SUBMITTER: Miura I 

PROVIDER: S-EPMC10443951 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature