Shared and organ-specific gene-expression programs during the development of the cochlea and the superior olivary complex.

ABSTRACT: The peripheral and central auditory subsystems together form a complex sensory network that allows an organism to hear. The genetic programs of the two subsystems must therefore be tightly coordinated during development. Yet, their interactions and common expression pathways have never been systematically explored. MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression and are essential for normal development of the auditory system. We performed mRNA and small-RNA sequencing of organs from both auditory subsystems at three critical developmental timepoints (E16, P0, P16) to obtain a comprehensive and unbiased insight of their expression profiles. Our analysis reveals common and organ-specific expression patterns for differentially regulated mRNAs and miRNAs, which could

SUBMITTER: Bordeynik-Cohen M 

PROVIDER: S-EPMC10443965 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature