Characterization and Investigation of Risk Factors for Late-Relapsing Hepatitis After Yellow Fever.

ABSTRACT:

Background

Late-relapsing hepatitis after yellow fever (LHep-YF) during the convalescent phase of the disease has been described during recent yellow fever (YF) outbreaks in Brazil. LHep-YF is marked by a rebound in liver enzymes and nonspecific clinical manifestations around 46-60 days after YF symptom onset.

Methods

Here we have characterized the clinical course and risk factors for LHep-YF using data from a representative cohort of patients who survived YF in Brazil, 2017-2018. A total of 221 YF-positive patients were discharged from the infectious disease reference hospital in Minas Gerais and were followed up at 30, 45, and 60 days post-symptom onset.

Results

From 46 to 60 days post-symptom onset, 16% of YF patients (n = 36/221) exhibited a rebound of aminotransf

SUBMITTER: Rezende IM 

PROVIDER: S-EPMC10444002 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature