Analytic Morphomics in Myositis-Related Interstitial Lung Disease.

ABSTRACT:

Purpose

Interstitial lung disease (ILD) is the most common non-musculoskeletal manifestation of idiopathic inflammatory myopathies (IIM). Identification of body composition change may enable early intervention to improve prognosis. We investigated muscle quantity and quality derived from cross-sectional imaging in IIM, and its relationship to ILD severity.

Methods

A retrospective cohort study assessing IIM of ILD patients (n = 31) was conducted. Two datasets separated in time were collected, containing demographics, biochemical data, pulmonary function testing and thoracic CT data. Morphomic analysis of muscle quantity (cross-sectional area) and quality (density in Hounsfield Units) on thoracic CT were analysed utilising a web-based tool allowing segmentation of muscle and f

SUBMITTER: O'Mahony AT 

PROVIDER: S-EPMC10444650 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature