Point-of-care diagnostics for rapid determination of prostate cancer biomarker sarcosine: application of disposable potentiometric sensor based on oxide-conductive polymer nanocomposite.

ABSTRACT: One of the most important reasons for an increased mortality rate of cancer is late diagnosis. Point-of-care (POC) diagnostic sensors can provide rapid and cost-effective diagnosis and monitoring of cancer biomarkers. Portable, disposable, and sensitive sarcosine solid-contact ion-selective potentiometric sensors (SC-ISEs) were fabricated as POC analyzers for the rapid determination of the prostate cancer biomarker sarcosine. Tungsten trioxide nanoparticles (WO₃ NPs), polyaniline nanoparticles (PANI NPs), and PANI-WO₃ nanocomposite were used as ion-to-electron transducers on screen-printed sensors. WO₃ NPs and PANI-WO₃ nanocomposite have not been investigated before as ion-to-electron transducer layers in potentiometric SC sensors. The designated

SUBMITTER: Yamani HZ 

PROVIDER: S-EPMC10444660 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature