The effect of pulse shape in theta-burst stimulation: Monophasic vs biphasic TMS.

ABSTRACT:

Background

Intermittent theta-burst stimulation (i) (TBS) is a transcranial magnetic stimulation (TMS) plasticity protocol. Conventionally, TBS is applied using biphasic pulses due to hardware limitations. However, monophasic pulses are hypothesised to recruit cortical neurons more selectively than biphasic pulses, predicting stronger plasticity effects. Monophasic and biphasic TBS can be generated using a custom-made pulse-width modulation-based TMS device (pTMS).

Objective

Using pTMS, we tested the hypothesis that monophasic iTBS would induce a stronger plasticity effect than biphasic, measured as induced increases in motor corticospinal excitability.

Methods

In a repeated-measures design, thirty healthy volunteers participated in three separate sessions, where mono

SUBMITTER: Wendt K 

PROVIDER: S-EPMC10444700 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature