Streptolysin S induces pronounced calcium-ion influx-dependent expression of immediate early genes encoding transcription factors.

ABSTRACT: Anginosus group streptococci (AGS) are opportunistic human pathogens of the oral cavity. The β-hemolytic subgroup of Streptococcus anginosus subsp. anginosus secretes streptolysin S (SLS) and exhibits not only hemolytic activity but also cytotoxicity toward cultured human cell lines. However, the detailed mechanism of action of SLS and the cellular responses of host cells have not yet been fully clarified. To determine the pathogenic potential of SLS-producing β-hemolytic S. anginosus subsp. anginosus, the SLS-dependent response induced in the human oral squamous cell carcinoma HSC-2 cells was investigated to determine the pathogenic potential of SLS-producing β-hemolytic S. anginosus subsp. anginosus. This study revealed that the Ca²⁺ influx and the expression of immediate earl

SUBMITTER: Yamada T 

PROVIDER: S-EPMC10444759 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature