Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy.

ABSTRACT: Response to immunotherapy widely varies among cancer patients and identification of parameters associating with favourable outcome is of great interest. Here we show longitudinal monitoring of peripheral blood samples of non-small cell lung cancer (NSCLC) patients undergoing anti-PD1 therapy by high-dimensional cytometry by time of flight (CyTOF) and Meso Scale Discovery (MSD) multi-cytokines measurements. We find that higher proportions of circulating CD8⁺ and of CD8⁺CD101^hiTIM3⁺ (CCT T) subsets significantly correlate with poor clinical response to immune therapy. Consistently, CD8⁺ T cells and CCT T cell frequencies remain low in most responders during the entire multi-cycle treatment regimen; and higher killer cell lectin-like rece

SUBMITTER: Leung EL 

PROVIDER: S-EPMC10444872 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature