Knockdown of biglycan reveals an important role in maintenance of structural and mechanical properties during tendon aging.

ABSTRACT: Biglycan, a small leucine-rich proteoglycan (SLRP), is involved in collagen fibrillogenesis and also acts as a signaling molecule. Although decorin has been considered as the primary SLRP in developing and maintaining tendon structure and mechanics, more recent work using inducible knockdown models suggests that biglycan is involved in tendon homeostasis. The purpose of the study was to determine the role of biglycan in tendon homeostasis to maintain mechanical and structural integrity in aged mice. Aged (485 days old) female Bgn^+/+ control (wild type [WT], n = 16) and 16 bitransgenic conditional Bgn^flox/flox mice (I-Bgn^-/- , n = 16) with a tamoxifen-inducible Cre (driven by ROSA) were utilized. After biglycan knockdown, the transgenic model demonstrated ef

SUBMITTER: Darrieutort-Laffite C 

PROVIDER: S-EPMC10444902 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature