Tumour-associated macrophages in gastric cancer: From function and mechanism to application.

ABSTRACT:

Background

Gastric cancer (GC) is a malignant tumour, with high morbidity and mortality rates worldwide. The occurrence and development of GC is a complex process involving genetic changes in tumour cells and the influence of the surrounding tumour microenvironment (TME). Accumulative evidence shows that tumour-associated macrophages (TAMs) play a vital role in GC, acting as plentiful and active infiltrating inflammatory cells in the TME.

Main body

In this review, the different functions and mechanisms of TAMs in GC progression, including the conversion of phenotypic subtypes; promotion of tumour proliferation, invasion and migration; induction of chemoresistance; promotion of angiogenesis; modulation of immunosuppression; reprogramming of metabolism; and interaction with th

SUBMITTER: Li J 

PROVIDER: S-EPMC10444973 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature