Identifying immune cell infiltration and effective diagnostic biomarkers in Crohn's disease by bioinformatics analysis.

ABSTRACT:

Background

Crohn's disease (CD) has an increasing incidence and prevalence worldwide. It is currently believed that both the onset and progression of the disease are closely related to immune system imbalance and the infiltration of immune cells. The aim of this study was to investigate the molecular immune mechanisms associated with CD and its fibrosis through bioinformatics analysis.

Methods

Three datasets from the Gene Expression Omnibus data base (GEO) were downloaded for data analysis and validation. Single sample gene enrichment analysis (ssGSEA) was used to evaluate the infiltration of immune cells in CD samples. Immune cell types with significant differences were identified by Wilcoxon test and Least Absolute Shrinkage and Selection Operator (LASSO) regression analys

SUBMITTER: Huang R 

PROVIDER: S-EPMC10445157 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature