Identification of cuproptosis and immune-related gene prognostic signature in lung adenocarcinoma.

ABSTRACT:

Background

Cuproptosis is a novel form of programmed cell death that differs from other types such as pyroptosis, ferroptosis, and autophagy. It is a promising new target for cancer therapy. Additionally, immune-related genes play a crucial role in cancer progression and patient prognosis. Therefore, our study aimed to create a survival prediction model for lung adenocarcinoma patients based on cuproptosis and immune-related genes. This model can be utilized to enhance personalized treatment for patients.

Methods

RNA sequencing (RNA-seq) data of lung adenocarcinoma (LUAD) patients were collected from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The levels of immune cell infiltration in the GSE68465 cohort were determined using gene set variatio

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10445162 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature