Adjuvant Chemotherapy Improves Survival for Children With Massive Choroidal Invasion of Retinoblastoma.

ABSTRACT:

Purpose

The purpose of this study was to investigate the effect of adjuvant chemotherapy on outcomes of children with massive choroidal invasion (MCI).

Methods

In this study, we reviewed the 5-year relapse-free survival (RFS) and overall survival (OS) of children diagnosed with MCI, managed with or without adjuvant chemotherapy. Excluded were children with additional other high-risk features (post-laminar optic nerve invasion, scleral invasion, or overt extraocular disease).

Results

Of 3566 children diagnosed with retinoblastoma, 2023 had enucleation, and 60 eyes of 60 children had pathology showing MCI without concomitant high-risk features. Enucleation was primary (22, 37%), or secondary (38, 63%) after failed eye salvage. Adjuvant systemic chemotherapy (median = 4,

SUBMITTER: Feng ZX 

PROVIDER: S-EPMC10445210 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature