Relative apical sparing in cardiac amyloidosis is not always explained by an amyloid gradient.

ABSTRACT:

Aims

Myocardial longitudinal strain (LS) by two-dimensional (2D) speckle-tracking echocardiography has a diagnostic and prognostic role in cardiac amyloidosis (CA). Typically, the apical segments of the left ventricle (LV) are less affected by LS abnormalities, a finding called relative apical sparing (RELAPS). Whether a variable burden of CA might explain the RELAPS remains unknown.We aimed to evaluate the extent, distribution, and deposition pattern of amyloid in autopsy hearts of CA patients and to correlate the histopathology findings with 2D echocardiography.

Methods and results

This is a retrospective study of whole heart specimens of CA patients who died and underwent autopsy and 2D echocardiography. Amyloid burden quantification was assessed by histomorphometry in ea

SUBMITTER: De Gaspari M 

PROVIDER: S-EPMC10445246 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature