Prophylactic antibiotic use for infective endocarditis: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Infective endocarditis (IE) is a devastating disease with a 50% 1-year mortality rate. In recent years, medical authorities across the globe advised stricter criteria for antibiotic prophylaxis in patients with high risk of IE undergoing dental procedures. Whether such recommendations may increase the risk of IE in at-risk patients must be investigated.

Design

Prospectively registered systematic review and meta-analysis.

Data sources

Medline, Embase, Scopus and ClinicalTrials.gov were searched through 23 May 2022, together with an updated search on 5 August 2023.

Eligibility criteria

All primary studies reporting IE within 3 months of dental procedures in adults >18 years of age were included, while conference abstracts, reviews, case reports and cas

SUBMITTER: Lean SSH 

PROVIDER: S-EPMC10445353 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature