Population-level antagonism between FGF and BMP signaling steers mesoderm differentiation in embryonic stem cells.

ABSTRACT: The mesodermal precursor populations for different internal organ systems are specified during gastrulation by the combined activity of extracellular signaling systems such as BMP, Wnt, Nodal and FGF. The BMP, Wnt and Nodal signaling requirements for the differentiation of specific mesoderm subtypes in mammals have been mapped in detail, but how FGF shapes mesodermal cell type diversity is not precisely known. It is also not clear how FGF signaling integrates with the activity of other signaling systems involved in mesoderm differentiation. Here, we address these questions by analyzing the effects of targeted signaling manipulations in differentiating stem cell populations at single-cell resolution. We identify opposing functions of BMP and FGF, and map FGF-dependent and -independent mesod

SUBMITTER: Gattiglio M 

PROVIDER: S-EPMC10445724 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature