Uncharacterized protein C17orf80 - a novel interactor of human mitochondrial nucleoids.

ABSTRACT: Molecular functions of many human proteins remain unstudied, despite the demonstrated association with diseases or pivotal molecular structures, such as mitochondrial DNA (mtDNA). This small genome is crucial for the proper functioning of mitochondria, the energy-converting organelles. In mammals, mtDNA is arranged into macromolecular complexes called nucleoids that serve as functional stations for its maintenance and expression. Here, we aimed to explore an uncharacterized protein C17orf80, which was previously detected close to the nucleoid components by proximity labelling mass spectrometry. To investigate the subcellular localization and function of C17orf80, we took advantage of immunofluorescence microscopy, interaction proteomics and several biochemical assays. We demonstrate that C

SUBMITTER: Potter A 

PROVIDER: S-EPMC10445727 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature