Core conserved transcriptional regulatory networks define the invasive trophoblast cell lineage.

ABSTRACT: The invasive trophoblast cell lineages in rat and human share crucial responsibilities in establishing the uterine-placental interface of the hemochorial placenta. These observations have led to the rat becoming an especially useful animal model for studying hemochorial placentation. However, our understanding of similarities or differences between regulatory mechanisms governing rat and human invasive trophoblast cell populations is limited. In this study, we generated single-nucleus ATAC-seq data from gestation day 15.5 and 19.5 rat uterine-placental interface tissues, and integrated the data with single-cell RNA-seq data generated at the same stages. We determined the chromatin accessibility profiles of invasive trophoblast, natural killer, macrophage, endothelial and smooth muscle cell

SUBMITTER: Vu HTH 

PROVIDER: S-EPMC10445752 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature